ARYL-HYDROCARBON HYDROXYLASE IN MOUSE MAMMARY-GLAND

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (11) , 4125-4129
Abstract
The specific activity of aryl hydrocarbon hydroxylase in the mammary gland was measured in 6 mouse strains comprising mammary cancer susceptibility and resistance, under basal conditions, and after pretreatment with 3-methylcholanthrene (3MC). No correlation was observed between the ease of 3MC enhanced mammary tumorigenesis and the basal or induced specific activity of aryl hydrocarbon hydroxylase. In AKR/J and A+/Ki mice, only minor enhancement in aryl hydrocarbon hydroxylase was seen on injection of 3MC. C57BL/6J and C3Hf/HeTex mammary glands responded the most in this regard. The inability of the AKR/J or A+/Ki mice to respond was not due to their inability to Absorb 3MC from the peritoneal cavity and transmit the polycyclic hydrocarbon to the mammary gland.