?? T-cell receptor-positive cells of human skin. II. Appearance in delayed-type hypersensitivity reaction

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Abstract
In order to investigate the distribution and involvement of human γδ T-cell receptor-positive (TCR+) cells in delayed-type hypersensitivity reactions of the skin, we examined the occurrence and kinetics of γδ TCR+ cells during skin reactions of allergic contact dermatitis. In normal human skin sections, γδ TCR+ cells were scarce. In allergic contact dermatitis from DNCB, increased γδ TCR+ cells were observed both in the epidermis and in the dermis from 48 h after the challenge. Most of the γδ TCR+ cells were TCRδ1+ δTCS1− BB3+ TiγA+ (Vδ1− Vδ2+ Vγ9+). The percentage of γδ TCR+ cells in the peripheral blood remained unchanged and a few γδ TCR+ cells in the skin lesions proliferated in situ. It is suggested that the γδ TCR+ cells in skin lesions of allergic contact dermatitis may not be involved in initiation of delayed-type hypersensitivity but may have some other roles responding to factors induced in the reaction.