Beneficial effect of cyclosporin A on the lymphocytic choriomeningitis virus infection in mice
- 1 January 1984
- journal article
- Published by Wiley in European Journal of Immunology
- Vol. 14 (11) , 1064-1066
- https://doi.org/10.1002/eji.1830141120
Abstract
The effect of cyclosporin A on the course of lymphocytic choriomeningitis virus infection in mice was investigated. Evidence is presented that administration of this immunosuppressive drug spares a majority of lethally infected mice. This beneficial effect is different from the one obtained with other treatments leading to the abolition of T cell functions. Surviving animals rapidly eliminate the virus and produce high titers of neutralizing IgG antibodies.Keywords
This publication has 13 references indexed in Scilit:
- Evidence for the presence of T lymphocytes mediating lymphocytic choriomeningitis virus-specific delayed-type hypersensitivity in meningeal infiltrates of infected miceAnnales de l'Institut Pasteur / Virologie, 1983
- Fatal Meningitis following Lymphocytic Choriomeningitis Virus Infection Reflects Delayed‐Type Hypersensitivity Rather than CytotoxicityScandinavian Journal of Immunology, 1983
- Suppressive effects of cyclosporin A on the induction of alloreactivity in vitro and in vivo.The Journal of Immunology, 1981
- Cyclosporin a inhibits the proliferative response and the generation of helper, suppressor and cytotoxic T-cell functions in the autologous mixed lymphocyte reactionCellular Immunology, 1981
- The effects of cyclosporin A on the immune systemImmunology Today, 1981
- Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.The Journal of Immunology, 1980
- IMMUNOPATHOGENESIS OF ACUTE CENTRAL NERVOUS SYSTEM DISEASE PRODUCED BY LYMPHOCYTIC CHORIOMENINGITIS VIRUSThe Journal of Experimental Medicine, 1972
- Effects of Anti-Thymocyte Serum on Lymphocytic Choriomeningitis (LCM) Virus Infection in MiceExperimental Biology and Medicine, 1967
- Protective Effect of Neonatal Thymectomy on Mouse LCM InfectionExperimental Biology and Medicine, 1963
- Demonstration, properties and significance of neutralizing antibodies in mature mice immune to lymphocytic choriomeningitis (LCM)Archiv für die gesamte Virusforschung, 1960