HEMOLYTIC ANEMIA PRODUCED BY THE FEEDING OF FAT AND CHOLINE

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Abstract
The adm. of 2 doses each, daily, of 60 gs. of fat and 10 mgs. of choline chloride/kg, to 3 normal dogs caused rapid reductions of 20-37% in their erythrocyte counts, accompanied by significant elevations of icteric indices. The addition of 1/4 lb. of butter and 400 mg. of choline to the breakfasts of 2 human subjects caused depression of their red blood cell counts during the following 36 hrs., followed by reticulo-cytosis.

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