REGIONAL BLOOD-FLOW AND THE LOCALIZATION OF LYMPHOBLASTS IN THE SMALL-INTESTINE OF THE MOUSE .2. THE EFFECT OF A PRIMARY ENTERIC INFECTION WITH TRICHINELLA-SPIRALIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (4) , 963-971
Abstract
125I-UdR-labeled mesenteric lymph node cell localization in the small intestine and the cardiac output fraction delivered to this organ in mice was examined. Concurrent measurements of these 2 phenomena in normal animals showed that there was a significant correlation between lymphoblast localization and the regional blood flow distribution along the small intestine. In mice undergoing enteric infection with T. spiralis, the nature of the connection between lymphoblast localization and small intestine blood flow distribution was altered. More lymphoboast label accumulated in the small intestine of infected mice than in uninfected animals even at stages of the infection when no alteration in the cardiac output proportion received by the small intestine had occurred. Enhanced lymphoblast accumulation occurred in different infected small intestine segments as the infection proceeded and these changes paralleled the way in which the parasite burden was distributed in the intestine. Lymphoblast accumulation kinetics in infected and uninfected small intestine was examined under circumstances where the delivery of blood-borne labeled cells was the same. Both increased lymphoblast entry and enhanced lymphoblast retention in the parasitized small intestine.