MIGRATION OF LYMPHOBLASTS TO SMALL-INTESTINE .1. EFFECT OF TRICHINELLA-SPIRALIS INFECTION ON MIGRATION OF MESENTERIC LYMPHOBLASTS AND MESENTERIC T LYMPHOBLASTS IN SYNGENEIC MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 31  (5) , 723-730
Abstract
The migration of [125I]UdR[deoxyuridine]-labeled mesenteric lymph node cells in NIH strain mice was investigated at various times after infection with the intestinal parasite T. spiralis. T. spiralis produced an enhanced accumulation of mesenteric immunoblasts in the small intestine at 2 and 4 days after infection but not at later times. The enhanced migration occurred when using cells from uninfected and infected donors, denoting an absence of antigenic specificity. This effect is not secondary to a reduced arrival of cells at sites away from the gut in infected mice, but to a primary increase of the arrival in the small intestine. Mesenteric T [thymus-derived] lymphoblasts (separated on a nylon-wool column) migrated to the small intestine of uninfected recipients, and appear to be a major portion of the population which migrate to the gut of infected recipients. These results were confirmed using 51Cr to label mesenteric cells. The parasite causes the small intestine to become more attractive or retentive for mesenteric blast cells early during infection.