Relapse of Duodenal Ulcer after Treatment with Trimipramine/Antacids or Cimetidine/Antacids

Publisher Website
Google Scholar
Abstract
Patients (93) with duodenal ulcer were treated with trimipramine, 25 mg at night, cimetidine, 400 mg at night or cimetidine, 1000 mg/day. All patients were given 20 ml antiacids 1 and 3 h after meals. The healing rates after 6 wk treatment were 86, 85 and 100% in the 3 groups, respectively (differences not significant). After healing of the ulcers 88 of the patients were checked monthly for 1 yr to study relapse rate. Endoscopy was performed on recurrence of symptoms suggesting relapse and after 6 and 12 mo. in all asymptomatic patients. Relapse was diagnosed in 64% of patients in the trimipramine-treated group, in 48% in the 400 mg cimetidine group and in 54% in the 1000 mg cimetidine group (differences not significant). Ulcer recurrence was not more common after treatment with a standard dose of cimetidine than after a low dosage of cimetidine or trimipramine.