Serologically Cross-reactive Polypeptides in Vaccinia, Cowpox and Shope Fibroma Viruses

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Abstract
An immunoprecipitation method coupled with SDS[sodium dodecyl sulfate]-polyacrylamide gel electrophoresis (SDS-PAGE) was used to identify the serologically cross-reactive polypeptides in Orthopoxvirus (vaccinia and cowpox viruses) and Leporipoxvirus (Shope fibroma virus). Two early and 4 late polypeptides in [rabbit kidney RK13] cells infected with vaccinia or cowpox virus were specifically immunoprecipitated with antiserum against Shope fibroma virus. Two early and 2 late polypeptides in cells infected with Shope fibroma virus cross-reacted with antiserum against vaccinia virus and antiserum against cowpox virus. The possibility of the common polypeptides being related to nucleoprotein antigen in these cross-reactive polypeptides was discussed.