HIGH LEVEL OF A NERVE GROWTH FACTOR IN THE SERUM OF A PATIENT WITH MEDULLARY CARCINOMA OF THE THYROID GLAND
- 1 February 1977
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 6 (2) , 105-112
- https://doi.org/10.1111/j.1365-2265.1977.tb02001.x
Abstract
The serum of a patient with a familial medullary thyroid carcinoma showed levels of a factor, active in the nerve growth factor (NGF) bioassay and cross‐reacting immunologically with mouse NGF, 20‐1000 times higher than sera from normal controls or from patients with unrelated tumours. Variations of the level of this factor in the serum closely correlated with the progression of the disease. One of the patient's sons, apparently clinically normal, also showed high levels of this factor in the serum, raising the possibility that abnormality in the production of this factor could be present at an early stage of the disease.Keywords
This publication has 30 references indexed in Scilit:
- Binding of Nerve Growth Factor Receptor in Sympathetic GangliaProceedings of the National Academy of Sciences, 1973
- Medullary Thyroid Carcinoma Detected by Serum Calcitonin AssayArchives of Surgery, 1972
- Assay of nerve growth factor (NGF) in subcellular fractions of peripheral tissues by micro complement fixationBrain Research, 1971
- Nerve Growth Factor from Mouse Submaxillary Gland: Amino Acid SequenceProceedings of the National Academy of Sciences, 1971
- Abnormal Intradermal Histamine Reaction in the Syndrome of Pheochromocytoma, Medullary Carcinoma of the Thyroid Gland and Multiple Mucosal NeuromasNew England Journal of Medicine, 1971
- A neuropolyendocrine syndrome: Mucosal neuromas, pheochromocytoma, and medullary thyroid carcinomaOral Surgery, Oral Medicine, Oral Pathology, 1971
- Elevated Histaminase Activity in Medullary Carcinoma of the Thyroid GlandNew England Journal of Medicine, 1970
- The role of the tryptophan residues in the activity of the nerve growth factorBiochimica et Biophysica Acta (BBA) - Protein Structure, 1970
- THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEINProceedings of the National Academy of Sciences, 1969
- Familial Medullary Carcinoma Of The ThyroidAnnals of Surgery, 1967