AMODIAQUINE-INDUCED AGRANULOCYTOSIS - DRUG-INHIBITION OF MYELOID COLONIES IN THE PRESENCE OF PATIENTS SERUM
- 1 January 1985
- journal article
- research article
- Vol. 21 (4) , 331-334
Abstract
A patient who developed agranulocytosis following exposure to 3 drugs: amodiaquine, pyrimethamine and dipyrone was reported. The combination of amodiaquine with the patient''s serum, obtained during the agranulocytosis, inhibited in vitro granulocyte-monocyte colony-forming unit (CFU-GM) growth of autologous and allogeneic marrow. Amodiaquine-induced agranulocytosis is apparently immune in nature. This in vitro approach may be used to study the mechanism of drug-induced agranulocytosis, especially when patients are exposed to multiple drugs.This publication has 5 references indexed in Scilit:
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