Anticholesteremic Property of Lactobacillus Acidophilus Yogurt Fed to Mature Boars2

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Abstract
Three strains of Lactobacilus acidophilus (LA) were isolated from the feces of mature boars that were not being fed antibiotics from the Nebraska Gene Pool (NGP). All three LA isolates were screened in vitro for anticholesteremic and antimicrobial activities. One strain, LA16, caused the greatest reduction in cholesterol and inhibited both Bacillus subtilis and Escherichia coli the most. LA16 was used to produce 16, 18.9-liter quantities of acidophilus yogurt (AY), over a period of 8 wk, for use as a feed ingredient in diets for the NGP boars. Colony forming units (cfu), pH, protein, energy, Ca and P were consistent across all 16 batches of yogurt. All of the 18 boars were fed a high-cholesterol diet for a period of 56 d at a rate of 2.268 kg/(h·d) to furnish 6.661 g/(h·d) of cholesterol. Nine of the boars then were fed 1.81 kg/(h·d) of a second diet that was supplemented with .454 kg/(h·d) of AY. The other nine boars were fed the original diet. Cholesterol intake was the same for the two dietary treatments. Blood samples were collected weekly from the brachial-jugular region and the sera were analyzed for lipids. Acidophilus yogurt reduced serum cholesterol (P < .01) and low density lipoproteins (P < .08), but it had no effect on serum triglycerides (P > .23) or on high density lipoproteins (P > .11).