Differential effects of training on the control of skeletal muscle perfusion

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Abstract
Endurance and high-intensity sprint training have been shown to alter skeletal muscle blood flow and factors that govern muscle perfusion under various conditions. Neither endurance nor sprint training alter skeletal muscle perfusion at rest but can result in an increase in muscle blood flow during the anticipation of exercise. The magnitude of the anticipatory increases in muscle blood flow is dependent on the intensity and duration of the prior training bouts and results from elevations in mean arterial pressure and decreases in vascular resistance in skeletal muscle. The decrements in skeletal muscle vascular resistance appear to be mediated through increases in muscle sympathetic cholinergic nerve activity or decreases in muscle sympathetic adrenergic nerve activity. During submaximal exercise, total muscle blood flow is either unchanged or slightly lower. However, a redistribution of muscle blood flow may occur following aerobic training, resulting in an enhanced perfusion of high-oxidative skeletal muscles and less flow going to low-oxidative muscles. The increased perfusion of the high-oxidative muscles may result from various factors including: a) increased recruitment of high-oxidative motor units, b) increased local release of metabolic vasodilator substances, c) qualitative changes in the metabolic substances released, d) decreased muscle sympathetic nerve activity, e) diminished sensitivity of the arterial vasculature to norepinephrine or other vasoconstrictor agents, f) enhanced endothelium-mediated dilation in the resistance vasculature, and g) an increased effectiveness of the skeletal muscle pump. Conversely, the decreases in blood flow to low-oxidative muscles may result from an enhanced autoregulatory responsiveness of the resistance vasculature. Endurance and sprint training increase muscle perfusion during exercise at ˙VO2max; this primarily appears to be the result of an enhanced pumping capacity of the heart to increase in maximal cardiac output. Many of the training-induced alterations in muscle blood flow and vascular structure are localized in the muscles that are most active during the training bouts. Therefore, differences in muscle recruitment patterns that occur with low-intensity endurance exercise and high-intensity sprint exercise may account for differences observed between these two training regimens.