A relation between the chain length of fatty acids and the slowing of gastric emptying

Publisher Website
Google Scholar
Abstract
Test meals of solutions and suspensions of K and Na salts of a series of saturated fatty acids, from C2 to C18, were given to healthy subjects. From the volume of these meals recovered after a fixed interval the relative effectiveness of the salts of the acids in slowing gastric emptying was assessed. On a molar basis the salts of fatty acids from acetic up to decanoic were relatively ineffective in slowing gastric emptying. The salts of fatty acids with 12-18 C atoms were much more effective than those with up to 10 C atoms. Myristate was the most effective of the salts. Buffering the test meals with 33 m[image] citrate increased the effectiveness of the salts in slowing gastric emptying.