LYMPHOSARCOMA: AN ANALYSIS OF FREQUENCY, DISTRIBUTION AND MORTALITY AT THE UNIVERSITY OF CALIFORNIA HOSPITAL, 1913-1948

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Abstract
Statistics are presented regarding age at onset, sex, duration of illness and mortality of 215 patients with lymphosarcoma. Cases were divided into 4 groups, as follows: 95 with lymphosarcoma primarily manifested by peripheral lymphadenopathy; 52 with visceral lymphosarcoma; 44 with special types of lymphosarcoma such as of the stomach, intestines, tonsil, bone or skin, and 24 with giant follicular lymphoma. Data are compared with 6 similar reports. The distribution suggests a shift toward more females, and suggests a higher mean age during recent yrs., but the differences are not significant statistically. The mean duration of illness in mos. for cases with lymphadenopathic lymphosarcoma was 34, for visceral lymphosarcoma 17, for special types of lymphosarcoma 37, and for giant follicular lymphoma 53. The 5 yr. survival of all 215 was 24%, varying from 2% in visceral lymphosarcoma to 46% in giant follicular lymphoma. Ten remained free of clinical evidence of disease from 5 to 21 yrs. after treatment with surgery or radiation; of these, 8 had lymphosarcoma of the stomach, intestines, tonsil, lung or soft tissue, and 2 had lymphosarcoma apparently limited to cervical or axillary lymph nodes. No significant differences in survival were found between chronologic periods of the study (1913-29, 1930-39 and 1940-48), or by sex. In the lymphadenopathic group, survival was significantly better in patients under 45 yrs. than in patients over 45 yrs.