Effect of Hemorrhage on Estimated Hepatic Blood Flow and Renal Blood Flow in Dogs

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Abstract
Estimated hepatic blood flow (EHBF), detd. by the Bromsulfalein (BSP) method using the technique of hepatic vein catheterization, arterial-hepatic vein oxygen difference, bromsulfalein extraction (E%) and renal blood flow (RBF), detd. as p-aminohippurate clearance, were measured in intact dogs before and after rapid blood loss, amounting to 1.3%-3.9% of body wt. Immediately following the bleeding the EHBF fell to 40%-81% of the control values. RBF decreased concomitant with the drop in EHBF after blood loss. The fall in EHBF was generally in proportion to, while the decrease in RBF was in each instance greater than the drop in mean arterial blood pressure. Within 23-70 min. after blood loss there was a spontaneous recovery of EHBF and RBF toward normal. Both E% and arterial-hepatic vein oxygen difference increased during the post-hemorrhage period.

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