THE EFFECT OF CORTISONE ACETATE UPON THE GROWTH OF THE WALKER RAT CARCINOMA AND UPON URINARY NON-PROTEIN NITROGEN, SODIUM, CHLORIDE AND POTASSIUM

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Abstract
20 intact male rats of the Sprague-Dawley strain having an initial wt. of approx. 300 g. were force-fed a medium carbohydrate diet. All of the rats were implanted with Walker carcinomas and 10 of them were given 5 mg. of cortisone acetate (subcut.) daily for 10 days. The admn. of the sterol caused a loss of body wt., a rise of urinary non-protein N and K and a temporary rise in urinary Na and chloride. The tumors gained in mass during the admn. of cortisone acetate although the hosts were in negative N balance, but the extent of growth during 10 days was definitely suppressed below that of the controls.