Studies on the Transmission and Pathology of a Viral-Induced Avian Nephroblastoma (Embryonal Nephroma)

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Abstract
Studies are made of a renal tumor, observed in chickens inoculated with BAI Strain A virus, which was formerly believed to cause only granuloblastic leukemia. Considered initially to be an adenocarcinoma, newer histopathological evidence indicates that it is a nephroblastoma. These experiments do not provide conclusive evidence of a separate etiologic agent for leukemia, although the leukemic manifestation was eliminated from the neoplastic spectrum of Strain A in the later transplant passages and in the filtrate test of one of them. These avlan renal tumors should be considered an additional member of the group of diseases known collectively as the avian leukosis complex.