Hemoperfusion and DNA Synthesis in the Rat Liver Part I: The Effect of Hemoperfusion on the Rate of DNA Synthesis

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Abstract
An investigation was made into whether charcoal hemoperfusion stimulates a hyperplastic response in the liver of the normal rat. Animals underwent hemoperfusion over Norit RBXI charcoal granules using a technique which allowed perfusion in the unrestrained and conscious state. Controls consisted of animals subjected to perfusion through empty columns and animals cannulated only. Body weight, liver weight, function and DNA synthesis were recorded at various times after completion of perfusion and control procedures. Charcoal hemoperfusion did not stimulate a hyperplastic response in the liver of the normal rat following perfusion and did not produce marked changes in body weight, liver weight and function.