Therapeutic implications of the mGluR theory of fragile X mental retardation
- 2 June 2005
- journal article
- review article
- Published by Wiley in Genes, Brain and Behavior
- Vol. 4 (6) , 393-398
- https://doi.org/10.1111/j.1601-183x.2005.00135.x
Abstract
Evidence is reviewed that the consequences of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation are exaggerated in the absence of the fragile X mental retardation protein, likely reflecting altered dendritic protein synthesis. Abnormal mGluR signaling could be responsible for remarkably diverse psychiatric and neurological symptoms in fragile X syndrome, including delayed cognitive development, seizures, anxiety, movement disorders and obesity.Keywords
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