Asymmetric synthesis of the β-lactam framework via a three-component coupling reaction
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1660-1662
- https://doi.org/10.1039/c39930001660
Abstract
The reaction of the chiral lithium amide 4 with the dienoate 5a provides regio- and stereo-selectively the β-amino ester 8 in essentially quantitative yield with >99% diastereoisomeric excess, which can be converted upon sequential treatment with LiNPri 2–B(OMe)3–MeCHO to the key intermediate 6 for the β-lactam 7 having the correct absolute configuration.Keywords
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