Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs
- 1 January 1999
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 16 (10) , 1514-1519
- https://doi.org/10.1023/a:1015040217741
Abstract
Purpose. To study oral absorption and brain penetration as a function of polar molecular surface area. Methods. Measured brain penetration data of 45 drug molecules were investigated. The dynamic...Keywords
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