Depression of Plasma FFA Levels in Unanesthetized Dogs by Single Intravenous Doses of Prostaglandin E1

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Abstract
Summary Intravenous injection of large doses of PGE1 into unanesthetized dogs caused marked decreases in plasma FFA levels lasting up to 40 minutes. On the other hand, vasodepression produced by injection of similar doses of PGE1-217 or by injection of nitroglycerin produced no fall in FFA levels, but instead a slight rise. This is interpreted as a response to sympathetic discharge induced by vasodepressor agents that do not share the ability of PGE1 to block the lipolytic action of epinephrine on adipose tissue. Simultaneous intravenous injection of PGE1and epinephrine diminished or abolished the lipid-mobilizing action of the latter, but glucose response was unaffected.