ABSORPTION, DISTRIBUTION AND EXCRETION OF THIOUREA

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Abstract
Methods for the estimation of thiourea have been modified for the detn. of the conc, of this substance in essentially all of the fluids and tissues of the body. Thiourea was rapidly absorbed from the gastro-intestinal tract and rapidly distributed throughout the fluids and tissues of the body. Its cones. in different tissues varied widely. The distribution of thiourea correlated poorly with the water content of the body fluids and tissues. The apparent vol. of distribution greatly exceeded the actual distribution of body water. The substance was broken down in the body in a rapid and inconstant manner. No thiourea was excreted in the stools, but it appeared in the urine within 30 mins. after ingestion.

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