THE INFLUENCE OF ATROPIN AND PILOCARPIN ON THIRST (VOLUNTARY INGESTION OF WATER)

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Abstract
In all, 6 dogs were used, 3 normal and 3 in which the salivary glands had been extirpated. Repeated injections of small doses of atropin over a period of 3 days did not significantly alter the water intake of dogs with or without salivary glands. Large single doses of atropin (up to 20 mgm.) did not significantly alter the 2 hourly fluid intake of these dogs. Injections of pilocarpin, after a 2 day thirst period, did not diminish the water intake of normal dogs as compared with that of dogs which had been deprived of their salivary glands. Changes in water ingestion after injections of atropin or pilocarpin are probably caused by some other factor than drying or moistening of the mucous membranes of the mouth and pharynx by suppression of or increase of the salivary secretion.

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