Synthesis and Biological Activity of a Potent Renin Inhibitor of the Azapeptide Type
- 30 November 1994
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1994 (12) , 1231-1233
- https://doi.org/10.1002/jlac.199419941214
Abstract
A highly potent renin inhibitor of the azapeptide type (2) is synthesized by starting from the hydrazine derivative 3. This peptide analogue inhibits renin in the same range (nanomolar) as its purely peptidic original 2a, but reveals much higher specificity for renin than 2a does.Keywords
This publication has 16 references indexed in Scilit:
- Cysteine protease inhibition by azapeptide estersJournal of Medicinal Chemistry, 1992
- Synthesis of a new azapeptide with renin‐inhibiting propertiesEuropean Journal of Organic Chemistry, 1990
- Synthesis of a Renin Inhibitor of the Azapeptide TypeEuropean Journal of Organic Chemistry, 1989
- Inhibitors of human leucocyte elastase. Peptides incorporating an α-azanorvaline residue or a thiomethylene linkage in place of a peptide bondJournal of the Chemical Society, Perkin Transactions 1, 1987
- Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statineJournal of Medicinal Chemistry, 1985
- Azapeptides: A new class of angiotensin-converting enzyme inhibitorsBiochemical and Biophysical Research Communications, 1984
- Hydrazinverbindungen als Heterobestandteile in Peptiden. XVI. Synthese von 9‐Hydrazinoessigsäure‐, 9‐Azaglycin‐ und 5‐α‐Azaasparagin‐OxytocinJournal für Praktische Chemie, 1972
- Hydrazinverbindungen als Heterobestandteile in Peptiden. XV. Synthese von Eledoisin‐Octapeptiden mit den Carbazylresten Azaglycin und α‐Azaasparagin statt Glycin und AsparaginJournal für Praktische Chemie, 1972
- Peptidähnliche Systeme, I. α‐Semicarbazino‐(4)‐fettsäurereste als Bausteine neuartiger Oligo‐VerbindungenEuropean Journal of Inorganic Chemistry, 1964
- N- [2-Isopropyl-3-(L-aspartyl-L-arginyl)-carbazoyl]-L- tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine,1 an Isostere of Bovine Angiotensin IIJournal of the American Chemical Society, 1963