Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited Disease
- 6 May 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4290) , 664-666
- https://doi.org/10.1126/science.193183
Abstract
Guanosine 3',5'-monophosphate (cyclic GMP) metabolism in developing eye rudiments of Xenopus laevis embryos in culture is disrupted by the phosphodiesterase inhibitor isobutylmethylxanthine. At low concentrations of inhibitor the rudiments develop normally, but at higher concentrations of the inhibitor, cyclic GMP accumulates in the rudiments and the retinal photoreceptor cells degenerate selectively. The isobutylmethylxanthine-induced photoreceptor degeneration is associated with an accumulation of cyclic GMP and, in this respect, it stimulates an early biochemical defect in the inherited degenerative disease of rd mice.This publication has 5 references indexed in Scilit:
- Cyclic GMP: Control of concentration by light in retinal photoreceptorsBiochemical and Biophysical Research Communications, 1976
- A proposed link between debris accumulation, guanosine 3′,5′ cyclic monophosphate changes and photoreceptor cell degeneration in retina of RCS ratsExperimental Eye Research, 1976
- ENZYMIC BASIS FOR CYCLIC-GMP ACCUMULATION IN DEGENERATIVE PHOTORECEPTOR CELLS OF MOUSE RETINA1976
- Autoradiographic study of [3H]glucosamine incorporation by the developing retina of the clawed toad, Xenopus laevisExperimental Eye Research, 1975
- Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse RetinaScience, 1974