Photoreactivation of UV-induced pyrimidine dimers and erythema in the marsupial Monodelphis domestica.

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Abstract
Post-UV treatment of the gray, short-tailed opossum Monodelphis domestica with photoreactivating light (320-400 nm) suppressed the appearance of UV-induced erythema as evidenced by an increase in the dose of UV required to elicit an erythemal response. The average erythema dose for animals held in the dark following UV exposure was 620 .+-. 40 J/m2, whereas 2460 .+-. 110 J/m2 were required for erythema induction with animals exposed to 90 min of photoreactivating light post-UV. Pre-UV exposure to photoreactivating light had no effect on the UV induction of erythema. The dose-response for the photoreversal of pyrimidine dimers in epidermal DNA of M. domestica was similar to that for the photoreactivation of erythema induction. DNA is the primary chromophore involved in the induction of erythema. Pyrimidine dimers are the major DNA change responsible for its induction. M. domestica is a useful whole-animal system with which to determine the role of pyrimidine dimers in other photobiological responses of mammalian skin.