MECHANISMS OF GA-67 ACCUMULATION BY TUMORS - ROLE OF CELL-MEMBRANE PERMEABILITY
- 1 May 1988
- journal article
- research article
- Vol. 29 (5) , 663-668
Abstract
The effects of citrate ion on in vitro and in vivo uptake of [67Ga]citrate by tumor cells have been studied. Carrier-free [67Ga]citrate seems to follow the physical diffusion of citrate ions into the cell, and the presence of carrier gallium inhibits that diffusion, reducing considerably its uptake. These results appear to support the hypothesis that increased permeability of tumor cells is the principle cause of [67Ga]citrate accumulation by tumors.This publication has 5 references indexed in Scilit:
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