The effect of early cyclophosphamide treatment on the subsequent immunity of chickens to coccidial infections
- 1 June 1974
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 68 (3) , 323-330
- https://doi.org/10.1017/s0031182000045856
Abstract
Chicks were treated with cyclophosphamide during the first 3 days of life in order to effect chemical bursectomy. They subsequently showed a reduced capacity for the production of serum agglutinins toBrucella abortusand immunolysins to sporozoites ofEimeria tenella. They also developed a reduced immunity toE. tenellaorE. maximacompared with that produced in normal birds. The evidence provided by these experiments for the role of circulating antibodies in immunity to coccidiosis is discussed.Keywords
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