Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II)

Open Access
Publisher Website
Google Scholar
Abstract
The effects of [the antineoplastic drug] cis-dichlorodiammineplatinum II (DDP) on the [mouse] intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and return to control proliferative rate on day 7. Subsequent treatments led to suboptimal recovery for all treatment intervals. DDP induced a 6-fold increase in [3H]dT incorporation in the kidney by day 7 which remained high until day 21, and returned to near-control values by day 45. After a single DDP treatment, the recovery potential of kidneys, measured by the proliferative response to folic acid stress, demonstrated suboptimal proliferative reserve compartments for up to 45 days. The distinction between acute and delayed sensitivity to subsequent drug treatment was more apparent in the DDP-treated kidney than in the intestinal epithelium.