Treatment of intestinal helminths in Nigeria with triclofenol piperazine

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Abstract
A total of 158 Nigerian school youths were treated with triclofenol piperazine for infections with Ascaris lumbricoides, Necator americanus and Trichuris trichiura. The dosage scales used in the four trials (three for Trichuris) were; Trial 1: an average of 52.6 mg./kg. body wt. given in the morning as a single dose. Trial 2: an average of 52.0 mg./kg. given as two single doses on consecutive mornings. Trial 3: an average of 52.2 mg./kg. as two single doses on two mornings, one week apart. Trial 4: average ranges of 53.6, 63.7 and 88.6 mg./kg. as a single dose. All were given on an empty stomach in the morning. In Trials 2–4, the administration of the drug was accompanied by a sweetened, warm chocolate drink.