Reversed‐phase chromatography as a general method for determining octan‐1‐ol/water partition coefficients
- 1 April 1981
- journal article
- research article
- Published by Wiley in Pesticide Science
- Vol. 12 (2) , 219-227
- https://doi.org/10.1002/ps.2780120216
Abstract
Reversed‐phase high‐pressure liquid chromatography (h. p. l. c.) and thin‐layer chromatography (t. l. c.), on commercially available, reversed stationary phases, were used to determine the octan‐1‐ol/water partition coefficients (P) for 20 non‐ionic organic chemicals, consisting mainly of known pesticides in common use. Good correlation was found between log P values and both the logarithms of the capacity factor (k′), obtained by h. p. l. c., and the Rm values derived from t. l. c. The methods were found to be applicable over a range of more than six orders of magnitude in P values. In addition, the relation is shown between the P values of organic chemicals and their solubilities in water and in octan‐1‐01.Keywords
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