Studies on the net uptake of solutes by normal and crown-gall tumor cells.

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Abstract
The increased capacity of tumor cells to take up solutes from dilute solutions doubtless confers a very real selective advantage on that cell type. A large segment of metabolism concerned with cell growth and division is rendered functional by specific ions. Whether those ions penetrate in adequate numbers to the proper loci in a cell appears to be determined both by the properties of the membrane systems of the cell and by the concentration of ions in the medium in which the cell is growing. In a dilute salt solution such as is found in White''s basic culture medium, the membranes of the cell serve, in part at least, as important regulators of that segment of biosynthetic metabolism upon which autonomy in the plant tumor cell depends.

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