Selection by Site-Directed Antibodies of Small Regions of Peptides which are Ordered in Water

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Abstract
High resolution nuclear magnetic resonance has been used to study a short peptide which corresponds to the antigenic region of a larger peptide immunogen. This work shows that there is a strong conformational preference for a Type II β‐turn in solution. This observation has implications for the nature of the immunogenicity and antigenicity of peptide antigens as well as for the more general question of protein‐folding mechanisms.