Effects of Free Fatty Acids on Synaptosomal Amino Acid Uptake Systems

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Abstract
The Na+-dependent synaptosomal uptakes of proline, aspartic acid, glutamic acid and GABA were strongly inhibited by monounsaturated fatty acids. With oleic acid, half-maximal inhibition was observed at about 15 .mu.M. The Na+-independent uptakes of leucine, phenylalanine, histidine and valine were less sensitive to inhibition by the unsaturated fatty acids. In contrast, the uptakes of all of these amino acids were unaffected by saturated fatty acids. The inhibition of proline uptake (and that of the other Na+-dependent amino acids) by oleic acid was overcome by the addition of serum albumin and the data presented further indicate that the previously reported stimulation of proline uptake by albumin could be related to its fatty acid binding properties.

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