Reduction of Myocardial Reactive Hyperemia during Oxygen Breathing in Dogs

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Abstract
In 7 open-chest anesthetized mongrel dogs, the left anterior descending coronary artery was occluded for 20 s. Myocardial reactive hyperemia was recorded during air and O2 breathings. The excess blood flow during the reactive hyperemia was smaller and the duration of the reactive hyperemia was shorter during O2 breathing than during air breathing. The reduction of O2 demand during O2 breathing is a possible reason for the decreased reactive hyperemia and O2 administration is beneficial in relieving myocardial ischemia.