Theoretical and experimental study of transplacental diffusion

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Abstract
Steady transplacental diffusion from fetus to mother of tritiated water, antipyrine, urea, sodium, and chloride ions has been studied in the sheep. Diffusion of antipyrine and tritiated water is limited by the rates of uterine and umbilical flows in a way that simulates a concurrent system; the degree of limitation imposed by placental permeability is negligible. The diffusion of urea is limited by flow rates and placental permeability to approximately the same degree. The diffusion rates of sodium and chloride ions are almost entirely limited by placental permeability.

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