MONOCLONAL-ANTIBODY DEFINED T-CELL SUBSETS AND AUTOLOGOUS MIXED LYMPHOCYTE-REACTION IN DOWNS-SYNDROME

  • 1 January 1983
    • journal article
    • research article
    • Vol. 53  (1) , 25-30
Abstract
Peripheral blood from 21 non-institutionalized children with Down''s syndrome (DS) and 21 age and sex matched simultaneously studied healthy controls, was analyzed for monoclonal antibody defined T cells and T cell subsets, using a fluorescence activated cell sorter, and the autologous (AMLR) and allogeneic mixed lymphocyte reaction (MLR). Total T cells (9.6+), OKT4+ (helper/inducer phenotype) and anti-Tac+ (activated T) cells were present in comparable proportions to that observed in the control group. The proportion of OKT8+ (suppressor/cytotoxic phenotype) cells were significantly (P < 0.05) decreased when compared to healthy controls. The proliferative response in the AMLR and MLR were comparable to control group. The significance of the results is discussed.