Regulation of Extracellular Acid Protease in Mucor miehei

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Abstract
The zygomycete M. miehei is used by industry to produce an acid protease which coagulates milk in the process of making cheese. This is a preliminary study of the natural function of enzyme. Studies of control of the acid protease of M. miehei show that in a defined medium a protein must be present for enzyme to be produced. Enzyme activity was not derepressed in the absence of protein by limitation of nutrients. Cycloheximide blocked enzyme production. High levels of free amino acids (1%) repressed enzyme activity. There was repression of enzyme activity in the presence of high levels of glucose, ammonium tartrate and magnesium sulfate. Observations were compared to the results of similar studies in other fungal systems.

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