Bronchial Anaphylaxis in Actively Sensitized Sprague Dawley Rats: Studies on Mediators Involved **

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Abstract
SD rats actively sensitized to ovalbumin (OA) undergo bronchial anaphylaxis at i.v. challenge with a specific antigen. Experiments indicate that the main primary mediators of the respiratory anaphylaxis are serotonin [5HT] and product(s) of the cyclooxygenase pathway of arachidonic acid metabolism. This is the case whether the animals are sensitized with 10 or 100 .mu.g OA together with 100 mg alum, and whether they are examined 2-3 or 5-6 wk after sensitization. The bronchoconstrictory efficacy of exogenously added 5-HT varies with the immunization conditions of the animals; those given 100 .mu.g OA together with alum are more reactive to 5-HT at i.v. challenge than animals given 10 .mu.g OA and alum. Compounds known to affect the lipoxygenase pathway of arachidonic acid metabolism influence the bronchial anaphylactic reaction in different ways depending on immunization and test conditions. 5-HT and some not yet identified product(s) of cyclooxygenase/thromboxane synthetase are probably main mediators of allergen-induced bronchial anaphylaxis in the rat. Products of the lipoxygenase pathway play a minor direct role but may modulate the response.

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