GROWTH INHIBITION IN BONE AND BONE MARROW FOLLOWING TREATMENT WITH ADRENOCORTICOTROPIN (ACTH)
- 1 December 1948
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 43 (6) , 422-429
- https://doi.org/10.1210/endo-43-6-422
Abstract
The following changes were observed in the tibias of adult male rats treated with ACTH in doses of 1 and 3 mg. daily for 21 days: (1) retardation of chondrogenesis and osteogenesis and (2) atrophy of the red marrow with apparent replacement of it with fat. Variation of the diet, which was controlled by tube-feeding, did not modify these results significantly. Less notice-able changes were observed in the vertebrae.Keywords
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