Antipneumococcal and Antistaphylococcal Activities of Ranbezolid (RBX 7644), a New Oxazolidinone, Compared to Those of Other Agents
Open Access
- 1 March 2003
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (3) , 1148-1150
- https://doi.org/10.1128/aac.47.3.1148-1150.2003
Abstract
For 260 pneumococcal and 266 staphylococcal strains, ranbezolid MICs ranged from ≤0.06 to 4 μg/ml. The MICs for pneumococci were similar irrespective of the strains' β-lactam, macrolide, or quinolone susceptibilities, and ranbezolid MICs for coagulase-negative staphylococci were lower than those for Staphylococcus aureus . Ranbezolid was bacteriostatic against pneumococci. Ranbezolid MICs were similar to or lower than those of linezolid. Vancomycin and quinupristin-dalfopristin were also very active.Keywords
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