Calcium Phosphate Solubility in Urine as Measured by a Precipitation Test: Experimental Urolithiasis XIII

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Abstract
The authors studied the reason for supersolubility of calcium phosphate in urine. To the material under study 0.1 [image] calcium chloride was added followed by 0.1 [image] di-sodium hydrogen phosphate. The amount of Ca in the filtrate is considered as a measure of calcium phosphate solubility. Calcium was determined by either permanganate titration or flame technique. Marked temporary supersaturation could be produced in urine, often lasting several hours. When the period of supersaturation had ended, the true solubility in urine was still much greater than that in water. The substances in urine accounting for these differences are the urinary electrolytes, such as Na, K, Cl, and SO4; Mg and citrate; and an unidentified solubilizing agent.