Agelastatins C and D, New Pentacyclic Bromopyrroles from the Sponge Cymbastela sp., and Potent Arthropod Toxicity of (−)-Agelastatin A

Publisher Website
Google Scholar
Abstract
Two new agelastatins, C (3) and D (4), along with the known compound (−)-agelastatin A (1), were isolated from the Indian Ocean sponge Cymbastela sp. The structures were determined by analysis of spectroscopic data and chemical correlation of 4 with a common derivative 5, also prepared from 1. Agelastatin A (1) exhibited potent activity against brine shrimp (LC50 1.7 ppm) in addition to insecticidal activity against larvae of beet army worm, Spodoptera exigua, and corn rootworm, Diabrotica undecimpunctata.