Transmission electron microscopy of small numbers of sorted cells

Abstract
A new method that allows the transmission electron microscopic examination of as few as 1 × 104 cells obtained by flow cytometric sorting is described. The approach involves “sandwiching” fixed cells in an agarose case by a microcentrifugation system consisting of small‐diameter cell‐centrifugation tubes and subsequent processing of the cells by conventional techniques. The advantages offered by this method are discussed.