Icterus and Febrile Reactions in Response to Isonicotinic Acid Hydrazine

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Abstract
ISONICOTINIC acid hydrazine is a drug remarkably free of toxic reactions at the dosage levels ordinarily employed. The most common side effects relate to Central-nervous-system hyperexcitability and peripheral neuropathy.1 Drug fever and jaundice are infrequently reported, only a few documented cases of each being found in the literature. However, these toxic reactions are not uncommonly associated with para-aminosalicylic acid administration.2 Since this drug is often given together with isonicotinic acid hydrazine, it is of some importance to point out that certain of the side effects of both drugs may be similar.It was noted in early animal experiments that long-term . . .