Inhibition of Vasopressin Effects on the Uterus by a Synthetic Analogue

Publisher Website
Google Scholar
Abstract
A synthetic analog, deamino-ethyl-oxytocin, which competitively inhibits vasopressin action on uterine activity both in vitro and in animal experiments was developed. The uterine effect of this analog was studied during the recording of intrauterine pressure in 16 gynecologically healthy women. Increased uterine [myometrial] activity and dysmenorrhea-like pain was induced by infusing lysine vasopressin in a dose of 0.08 .mu.g/min. Deamino-ethyl-oxytocin inhibited vasopressin action, the threshold dose being .apprx. 200 .mu.g given as a single i.v. injection for .apprx. 20 min. When given intranasally the drug was also effective in inhibiting vasopressin-induced uterine activity and symptoms. Deamino-ethyl-oxytocin could be of therapeutic value in primary dysmenorrhea, a condition associated with increased vasopressin secretion.