INTER AND INTRA DIURNAL-VARIATIONS OF DNA, RNA AND PROTEIN SYNTHETIC ACTIVITY IN NEWBORN, INFANT AND YOUNG-ADULT MOUSE LIVERS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 25  (4) , 289-293
Abstract
3H thymidine, 3H uridine and 3H leucine were used for studying incorporation into macromolecules. DNA, RNA and protein were prepared by a modified Kirby procedure. The data obtained indicate fluctuation of DNA activity approximately at 5 day intervals with a decreasing tendency up to 50 days of age. In 15 day old mice, the peak of synthetic DNA activity was observed at 9 a.m. and the lowest values were found the next day at 6 a.m. The results should make it possible to speculate whether the hepatocarcinogenic effect of different compounds with or without a special affinity to induce hepatoma may be correlated to different macromolecular synthetic activity.