Fluorinase mediated C–18F bond formation, an enzymatic tool for PET labelling
- 18 January 2006
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 6,p. 652-654
- https://doi.org/10.1039/b516861a
Abstract
The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5′-fluoro-5′-deoxyadenosine, [18F]-5′-fluoro-5′-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.Keywords
This publication has 12 references indexed in Scilit:
- Enzymatic Fluorination in Streptomyces cattleya Takes Place with an Inversion of Configuration Consistent with an SN2 Reaction MechanismChemBioChem, 2004
- Crystal structure and mechanism of a bacterial fluorinating enzymeNature, 2004
- Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agentsJournal of Labelled Compounds and Radiopharmaceuticals, 2003
- Isolation and characterisation of 5′‐fluorodeoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleyaFEBS Letters, 2003
- Mechanism, Mutagenesis, and Chemical Rescue of a β-Mannosidase from Cellulomonas fimiBiochemistry, 2003
- Assay for the Enantiomeric Analysis of [2H1]-Fluoroacetic Acid: Insight into the Stereochemical Course of Fluorination during Fluorometabolite Biosynthesis in Streptomyces cattleyaJournal of the American Chemical Society, 2002
- Biosynthesis of an organofluorine moleculeNature, 2002
- Enzymatic Synthesis of Carbon−Fluorine BondsJournal of the American Chemical Society, 2001
- The fluorinated natural productsNatural Product Reports, 1994
- Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya.The Journal of Antibiotics, 1986