Effect of combined misonidazole and accelerated neon ions on a human melanoma transplanted into nude mice.

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Abstract
The response to accelerated Ne ions of human Nall melanoma cells growing in nude mice was measured by an in vitro colony-forming assay following in situ tumor irradiation in the midposition of a 10-cm extended-peak ionization region. Values of the relative biological effectiveness (RBE) for peak Ne ions compared with 60Co .gamma.-radiation were 3.2 and 3.4, respectively, at the 1% and 10% survival levels. Following irradiation with peak Ne ions, the repair of potentially lethal damage (PLD) was comparable to that observed after .gamma. irradiation. When misonidazole (1 mg/g i.p. dose) was administered in combination with extended-peak Ne ions, the drug enhancement ratio (ER) at the 1% survival level was 1.5 if the tumors were removed and plated in vitro immediately following irradiation, and 1.9 if tumor excision and plating were delayed for .gtoreq. 6 h. Administration of misonidazole completely inhibited PLD repair following .gamma. irradiation or extended-peak Ne ion irradiation.